Adrenal Contribution to Circulating Estrogens in Woman
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概要
- 論文の詳細を見る
To study the contribution of adrenal glands to circulating estrogens in woman, the concentrations of estrone (E<SUB>1</SUB>), estradiol-17β(E<SUB>2</SUB>), and estriol (E<SUB>3</SUB>) in adrenal and peripheral venous blood were measured by radioimmunoassay and the grandular secretion of estrogens after ACTH stimulation was investigated by analyzing the adrenal vein levels of these steroids in patients with breast cancer who were undergoing a therapeutic adrenal operation. Furthermore, adrenal secretion rates of estrogens and cortisol were estimated. It was shown that there existed greater concentrations of estrogens in adrenal vein than in peripheral blood; about 3 times higher for E<SUB>1</SUB> (p<0.001), and 2 times higher for E<SUB>2</SUB> and E<SUB>3</SUB> (p<0.05). Administration of ACTH caused a significant increase of E<SUB>1</SUB> and E<SUB>2</SUB> concentrations in adrenal venous blood to mean 150% of the basal levels that was comparable to the increase of cortisol. Apparent adrenal secretion rates of estrogens estimated under surgical situation were calculated to be 7.7±1.7 (M±SE)μg/day for E<SUB>1</SUB>, 1.9±0.3μg/day for E<SUB>2</SUB>, and 0.3±0.2μg/day for E<SUB>3</SUB>, while the secretion rate of cortisol was 52.7±8.2μg/min.<BR>The present study demonstrates that the direct adrenal secretion of not only E<SUB>1</SUB>, but E<SUB>2</SUB> and E<SUB>3</SUB> contributes to the circulating estrogen levels, and it is suggested that the adrenal glands might be responsible for the relatively important source of estrogen production in the aged woman.
- 社団法人 日本内分泌学会の論文
著者
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WASADA TARO
The Third Detartment of Internal Medicine, Faculty of Medicine, Kyushu University
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KATO KEN-ICHI
The Third Detartment of Internal Medicine, Faculty of Medicine, Kyushu University
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IBAYASHI HIROSHI
The Third Detartment of Internal Medicine, Faculty of Medicine, Kyushu University
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AKAMINE YASUO
The Third Department of Internal Medicine, Faculty of Medicine, Kyushu University
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NOMURA YASUO
Division of Breast Surgery, National Cancer Hospital
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WASADA TARO
The Third Department of Internal Medicine, Faculty of Medicine, Kyushu University
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KATO KEN-ICHI
The Third Department of Internal Medicine, Faculty of Medicine, Kyushu University
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IBAYASHI HIROSHI
The Third Department of Internal Medicine, Faculty of Medicine, Kyushu University
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