Calcium Ion as “Second Messenger” in Corticoidogenic Action of ACTH

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概要

• 論文の詳細を見る

• The correlation between corticoidogenesis and Ca<SUP>2+</SUP>-influx in the cell was investigated using isolated rat or bovine adrenocortical cells.<BR>1) ACTH-induced corticoidogenesis in both rat and bovine adrenocortical cells was enhanced in parallel with increasing concentrations of external Ca<SUP>2+</SUP>. In the bovine cells but not in the rat cells, moreover, the marked stimulatory effect of external Ca<SUP>2+</SUP> on the corticoidogenesis was observed despite the absence of ACTH. 2) Ca<SUP>2+</SUP>-influx and corticoidogenesis always occurred unitedly. 3) Verapamil markedly inhibited either corticoidogenesis or Ca<SUP>2+</SUP>-influx in response to ACTH. 4) The stimulatory effect of Ca<SUP>2+</SUP> on corticoidogenesis was completely blocked by cycloheximide.<BR>It was therefore suggested that Ca<SUP>2+</SUP> could regulate corticoidogenesis as a primary “second messenger” of ACTH through biosynthesis of so-called steroidogenic protein.

• 社団法人 日本内分泌学会の論文

著者

• Yanagibashi Kazutoshi

  Department Of Pharmacology The Jikei University School Of Medicine

• YANAGIBASHI KAZUTOSHI

  Department of Pharmacology, The Jikei University School of Medicine

関連論文

• CYTOCHROME P-450 CONTAINING PROTEIN-PROTEIN INTERACTIONS IN BOVINE ADRENOCORTICAL MITOCHONDRIA
• Studies on Adrenocorticotropic Hormone Receptor Using Isolated Rat Adrenocortical Cells
• Calcium Ion as “Second Messenger” in Corticoidogenic Action of ACTH
• A Possible Role of “Steroidogenic Factor” in the Corticoidogenic Response to ACTH; Effect of ACTH, Cycloheximide and Aminoglutethimide on the Content of Cholesterol in the Outer and Inner Mitochondrial Membrane of Rat Adrenal Cortex

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