Effect of Calcium Administration on Renal Responsiveness to Parathyroid Hormone in Pseudohypoparathyroidism Type I and II : In Comparion with Normals, Idiopathic and Surgical Hypoparathyroidism
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概要
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A31-year-old man and a12-year-old girl were diagnosed as pseudohypoparathyroidism (PHP) Type I because of a failure to respond to the administration of parathyroid hormone (PTH) with increased urinary excretion of phosphate and cyclic adenosine-3, 5-monophosphate (cAMP). A 22-year-old woman was diagnosed as PHP Type II because there was no increase in the urinary excretion of phosphate despite of a marked increase in urinary cAMP excretion. With the combined calcium-PTH infusion or PTH infusion after vitamin D therapy, renal response was improved in these patients. Also dibutyryl adenosine-3-5-cyclic monophosphate (dbcAMP) infusion evoked an increased urinary phosphate excretion in all of the patients. The metabolic defect of our patients with PHP Type I may be caused not by a lack or defective form of PTH-sensitive receptor adenylate cyclase complex but rather by an abnormal conformation in the plasma membrane-associated receptor adenylate cyclase enzyme complex in kidney. In the patient with PHP Type II, as cAMP generation is intact, the metabolic defect might be related to a defect of calcium mobilization in renal tubular cells in response to PTH.
- 社団法人 日本内分泌学会の論文
著者
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Tamura Yasushi
The Second Department Of Internal Medicine Chiba University School Of Medicine
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YAMAMOTO MASAHIRO
The Second Department of Internal Medicine, Chiba University School of Medicine
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KUMAGAI AKIRA
The Second Department of Internal Medicine, Chiba University School of Medicine
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YAMADA KENICHI
The Second Department of Internal Medicine, School of Medicine, Chiba University
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