Effect of the Bonito Insulin on the Insulin Release from Monolayer Culture of Rat Pancreas

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概要

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• The effect of bonito insulin on insulin release was examined in the monolayer culture of rat pancreatic β-cells. The β-cells were preincubated for 5 to 20hr with or without a small dose (100μU/m<I>l</I>) of bonito insulin in the medium containing 100mg% glucose. And then, they were incubated in 300mg% glucose alone or together with bonito insulin for 5hr. There was no significant difference between the IRI release from these n-cells with or without bonito insulin. The concentration of bonito insulin was augmented from 100μU/ml to 500, 1, 000 and 2, 000μU/ml. A significant inhibitory effect on the glucose-induced insulin release was observed only after the preincubation for 20hr with 2, 000μU/ml of bonito insulin.

• 社団法人 日本内分泌学会の論文

著者

• KANAZAWA YASUNORI

  The Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo

• OHGAWARA HISAKO

  The Diabetic Center, Tokyo Womens Medical College

• TASAKA YOSHIMASA

  The Diabetic Center, Tokyo Womens Medical College

• TASAKA YOSHIMASA

  The Diabetic Center, Tokyo Women's Medical College

関連論文

• Alterations of Insulin-Secreting Response to Glucose in Human Infants During the Early Postnatal Period
• Effect of the Bonito Insulin on the Insulin Release from Monolayer Culture of Rat Pancreas
• Effect of Exogenous Bonito Insulin on Endogenous Insulin Secretion in Dogs
• Human plasma C-peptide immunoreactivity: Its correlation with immunoreactive insulin in diabetes, and chronic liver and renal diseases.

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