Changes in Fat Content and Some Characteristics of Lipolytic Activity During Pregnancy and Lactation in Mouse Mammary Gland

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The amount of free fatty acid in the mouse mammary gland continuously increased throughout pregnancy and lactation, while the amount of triglyceride which had been stored in the gland rapidly decreased after parturition. Higher lipolytic activity in the gland was observed in pregnancy than in nonpregnant and lactating animals. The optimum pH of the activities before and after parturition were about 6 and 7, respectively, and the activities did not decrease at high ionic strength in contrast to the ion dependent inactivation described in lipoprotein lipase. Incubation of the enzyme extract of the lactating mouse mammary gland at 50°C for 10min led to a remarkable increase in the lipolytic activity measured at pH6.0, suggesting the existence of either an inactive form of the lipase whose optimum pH is6.0or some heat sensitive inhibitor (s) or inactivator (s) of the enzyme in the lactating mammary gland. The triglyceride stored in the gland in pregnancy will be consumed within the first 3rd days after parturition, and the lipases play an important role in the decomposition of the triglyceride.
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