Metabolism of 3, 3-Diiodothyronine and 3-Monoiodothyronine, and Effect of Potassium Cyanide and Dinitrophenol on Glucuronidation of Thyroxine in Cultured Rat Hepatoma Cells
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概要
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Rat hepatoma cells (R117-21B) metabolized 3, 3-diiodothyronine and 3-monoiodothyronine by sulfation and glucuronidation. Glucuronidation of iodothyronines (a mixture of 3, 3-diiodothyronine, -90%, and 3-monoiodothyronine, -10%) was very rapid and 83% of the total <SUP>125</SUP>I in the medium was their glucuronides after 8hr incubation with the cells at 37°C. Iodothyronine sulfates (-9% of the total <SUP>125</SUP>I) were also detected. No clear increase in free iodide was observed during the 8 hr incubation.<BR>The effect of KCN or dinitrophenol on glucuronidation of thyroxine was investigated. Both drugs inhibited glucuronidation, and dinitrophenol was more effective than KCN. Dinitrophenol accelerated the liberation of 1251-in the metabolism of thyroxine in the cultured rat hepatoma cells.
- 社団法人 日本内分泌学会の論文
著者
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Sorimachi Kenji
Department Of Microbiology Dokkyo University School Of Medicine
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Sorimachi Kenji
Department Of Microbiology Dokkyo University School Of Medicine Mibu
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YASUMURA Yosihiro
Department of Microbiology, Dokkyo University School of Medicine
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Niwa Akira
Department Of Microbiology Dokkyo University School Of Medicine
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Niwa A
Dokkyo Univ. Tochigi Jpn
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Yasumura Y
Dokkyo Univ. School Of Medicine Tochigi Jpn
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Yasumura Yosihiro
Department Of Microbiology Dokkyo University School Of Medicine
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NIWA Akira
Department of Microbiology, Dokkyo University School of Medicine
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