Changes in Plasma Progestin, Prolactin, LH and FSH at Luteal Activation with Phenobarbital Anesthesia in the Rat
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概要
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Progesterone (P), 20α-hydroxypregn-4-en-3-one (20α-OHP), prolactin (PRL), LH and FSH in peripheral blood plasma were measured during the early stages of phenobarbital-induced pseudopregnancy (PHB-PSP; Furudate, 1975) and the changes in these hormone levels were compared with those during the 5-day estrous cycle and early stages of ordinary pseudopregnancy (PSP) induced by cervical stimulation.<BR>During the cycle, surging releases of LH, FSH and PRL, occurred in the afternoon of the first day of vaginal estrus (E<SUB>1</SUB>) and levels of these hormones were low during the other stages. Two large rises in P were observed ; one in the afternoon of day E<SUB>1</SUB> and the other during 2 days of vaginal diestrus (D<SUB>1</SUB> and D<SUB>2</SUB>). 20α-OHP showed daily diurnal rises sometime between 1600 and 2300 hr.<BR>A phenobarbital (PHB) injection (100mg/kg, sc) at 1900 hr on D<SUB>1</SUB> initiated daily PRL surges, which were similar to those observed following cervical stimulation though of less magnitude, without altering the levels of LH and FSH significantly. Continued elevation of P and lowering of 20α-OHP levels were observed as during the ordinary PSP.<BR>Continued vaginal diestrus of PHB-PSP was blocked by simultaneous injections of bromoergocryptine (CB-154; 1mg, sc) and PHB. In addition, the PSP-like vaginal diestrus was evident in all the rats receiving PRL administration twice daily for 3 consecutive days, starting at 2100 hr on D<SUB>1</SUB>. Therefore, PRL surges induced by PHB administration will be solely responsible for the luteal functionalization in PHB-PSP rats.
- 社団法人 日本内分泌学会の論文
著者
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KANEKO SHIGERU
Laboratory of Veterinary Physiology, Kitasato University School of Veterinary Medicine and Animal Sc
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KANEKO SHIGERU
Laboratory of Veterinary Physiology, Kitasato University School of Veterinary Medicine and Animal Science