Age and seasonal variations in the serum levels of 25-hydroxyvitamin D and 24,25-dihydroxyvitamin D in normal humans.
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概要
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Serum concentrations of 25-hydroxyvitamin D (25-OH-D) and 24, 25-dihydroxyvitamin D [24, 25-(OH) <SUB>2</SUB>-D] were measured in lipid extracts of 1m<I>l</I> of human sera by a competitive protein binding assay. 25-OH-D and 24, 25-(OH) <SUB>2</SUB>-D were isolated from the lipid extracts by Sephadex LH-20 column chromatography. The 24, 25-(OH) <SUB>2</SUB>-D fraction on the Sephadex LH-20 columns were further purified by high pressure liquid chromatography prior to assay. Serum levels of 25-OH-D and 24, 25-(OH) <SUB>2</SUB>-D in normal males were similar to those in normal females throughout each age group. Serum levels of 25-OH-D and 24, 25-(OH) <SUB>2</SUB>-D in newborns were 8.28±1.68ng/m<I>l</I> (mean±SD) and 0.55±0.16ng/ml, respectively, which were significantly (p<0.001) lower than those in adults (21.3±4.8ng/m<I>l</I> of 25-OH-D and 1.55±0.31ng/ml of 24, 25-(OH) <SUB>2</SUB>-D). A seasonal variation was demonstrated in serum levels of 24, 25-(OH) <SUB>2</SUB>-D as well as those of 25-OH-D. Serum levels of 24, 25-(OH) <SUB>2</SUB>-D were highly correlated (γ=0.884, p<0.001) with those of 25-OH-D in normal human subjects, and the percentage ratio of 24, 25-(OH) <SUB>2</SUB>-D/25-OH-D was 7.4±1.4%(mean±SD), irrespective of age or seasonal variations.
- 社団法人 日本内分泌学会の論文
著者
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Suda Tatsuo
Department Of Biochemistry School Of Dentistry Showa University
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YATA Junichi
Department of Pediatrics, Tokyo Medical and Dental University
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Kano Kenichi
Department Of Pediatrics Dokkyo Medical University School Of Medicine
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Yoshida Hisashi
Department Of Applied Biology Faculty Of Textile Science And Technology Shinshu University
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YOSHIDA HISASHI
Department of Pediatrics, School of Medicine, Tokyo Medical and Dental University
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KANO KENICHI
Department of Pediatrics, School of Medicine, Tokyo Medical and Dental University
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YATA JUNICHI
Department of Pediatrics, School of Medicine, Tokyo Medical and Dental University
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SUDA TATSUO
Department of Biochemistry, Showa University Dental School
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- Age and seasonal variations in the serum levels of 25-hydroxyvitamin D and 24,25-dihydroxyvitamin D in normal humans.