Differential Effects of Prostaglandin F<SUB>2α</SUB> on Oxytocinergicand Non-oxytocinergic Neurones in the Paraventricular Nucleus of the Lactating Rat

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概要

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• The effects of the prostaglandin F<SUB>2α</SUB> (PGF<SUB>2α</SUB>) given into the third cerebral ventricle on the unit activity of neurosecretory neurones in the paraventricular nucleus (PVN) were studied in urethane-anesthetized rats. The firing activity of PVN neurones was recorded extracellularly and 50 neurones were antidromically identified as neurosecretory neurones. Thirty of them were classified oxytocinergic neurones because they gave a burst of action potential 12-15 sec before reflex milkejection and the remaining twenty PVN neurones which showed no response prior toreflex milk ejections were regarded as non-oxytocinergic ones.<BR>Twenty-five (83%) of the 30 oxytocinergic neurones increased in the firing rate following the intraventricular (IVT) injection of PGF<SUB>2α</SUB> (500ng in 1μ<I>l</I> of isotonic saline) and the responses lasted for about 20-30min. The remaining 5 (17%) oxytocinergic neurones showed no response in the firing rate to IVT PGF<SUB>2α</SUB>. Fifteen (75%) of the20nonoxytocinergic neurones decreased in the firing activity in response to IVT PGF<SUB>2α</SUB>, and the remaining 5 (25%) of them showed no response. IVT injection of isotonic saline (1μEl) did not affect the firing activityof both the oxytocinergic and nonoxytocinergic cells. The intramammary pressure was slightly increased by the IVT administration of PGF<SUB>2α</SUB>.<BR>These findings indicate that IVT PGF<SUB>2α</SUB> has a differential action on oxytocinergic and non-oxytocinergic neurones in rats.

• 社団法人 日本内分泌学会の論文

著者

• NEGORO HIDEO

  Department of Physiology, Fukui Medical School

• AKAISHI TAKAO

  Department of Physiology, Niigata University School of Medicine

関連論文

• Pulsatile Secretion of Prolactin and Oxytocin During Nursing in the Lactating Rat
• Differential Effects of Prostaglandin F2α on Oxytocinergicand Non-oxytocinergic Neurones in the Paraventricular Nucleus of the Lactating Rat
• Effect of Anterior or Posterior Deafferentation of the Hypothalamus on Unit Activity in the Paraventricular Nucleus of Ovariectomized Female Rats with or without Estrogen Treatment
• Effect of Estrogen Treatment on Plasma Oxytocin and Vasopressin in Ovariectomized Rats
• Effect of rise in plasma osmotic pressure on the milk-ejection reflex in the rat.

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