Correlation of T<SUB>4</SUB> to T<SUB>3</SUB> Converting Activity with T<SUB>3</SUB> Concentration in Rat Tissues

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概要

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• The correlation between T<SUB>4</SUB> 5-deiodinase activity and thyroid hormone concentration in rat tissues was sought. Studies with normal and thyroidectomized rats indicated a significant correlation of the hepatic T<SUB>3</SUB> concentration with the enzymeactivity in liver homogenate (r=0.80, p<0.01) or in liver microsomes (r=0.08, p<0.01).The correlation between the hepatic T<SUB>4</SUB> concentration and activity of the enzyme was less significant (r=0.55, p<0.05 for homogenate, and r=0.66, p<0.01 for micrsomes). The degree of T<SUB>4</SUB> 5-deiodinase activity in various organs was found to increase in line with tissue concentration of T<SUB>3</SUB>. It seems likely that the level of T<SUB>4</SUB> 5-deiodinase activity is controlled by the tissue concentration of T<SUB>3</SUB>.

• 社団法人 日本内分泌学会の論文

著者

• Imai Yukihiro

  First Department Of Pathology Kobe University School Of Medicine

• Nishikimi Morimitsu

  Department Of Biochemistry Wakayama Medical University

• YAMAUCHI KAZUYUKI

  First Department of Internal Medicine, Nagoya Uniuersity School of Medicine

• KITAHARA HIDEMI

  First Department of Internal Medicine, Nagoya Uniuersity School of Medicine

• IMAI YUKIHIRO

  First Department of Internal Medicine, Nagoya Uniuersity School of Medicine

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