Hormonal Control of 5α-Reductase Activity in Hamster Sebaceous Glands
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概要
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The effect of castration on total 5α-reductase activity in transforming testosterone to 5α-reduced metabolites was studied in the sebaceous gland of male hamsters. The mean enzyme activity increased to more than twice the control level as early as 4days after castration and this increase remained almost unchanged at 14, 21 and 63days after castration. The administration of testosterone propionate or 5α-dihydrotestosterone to castrates led to a complete inhibition of the increase in enzyme activity and this inhibitory effect was blocked by cyproterone acetate. These data indicate that androgens may be regulators of 5α-reductase activity in the sebaceous gland of hamsters.
- 社団法人 日本内分泌学会の論文
著者
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Itami Satoshi
Department Of Dermatology Course Of Molecular Medicine Graduate School Of Medicine Osaka University
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Takayasu Susumu
Department Of Dermatology Oita Medical University
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