Reversible Hypertension Caused by Calcium Overloading in a Patient with Postoperative Hypoparathyroidism
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概要
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A 37-year-old woman with postoperative hypoparathyroidism had hypertension, and elevated plasma renin activity (PRA) and subsequent hyperaldosteronism during a twomonth hypercalcemic period caused by vitamin D and excessive calcium supplements. The hypertension with elevated PRA, however, was resistant to the angiotensin II (AII) analog [Sar<SUP>1</SUP>, Ile<SUP>8</SUP>] AII. PRA further increased and plasma aldosterone decreased in response to the [Sar<SUP>1</SUP>, Ile<SUP>8</SUP>] AII. When the patient became normocalcemic, normotensive and normoreninemic, calcium gluconate (5mg calcium/kg/h) was infused for one hour. The calcium infusion reproduced hypercalcemic hypertension mediated by an increase in total peripheral resistance.<BR>These observations suggest that the hypertension observed while taking vitamin D and excessive calcium supplements may be caused by a direct effect of calcium on peripheral blood vessels and the renin-angiotensin system may play a negligible role.
- 社団法人 日本内分泌学会の論文
著者
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KIGOSHI Toshikazu
Division of Endocrinology, Department of Internal Medicine, Kanazawa Medical University
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UCHIDA Kenzo
Division of Endocrinology, Department of Internal Medicine, Kanazawa Medical University
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YAMAMOTO IKUO
Division of Endocrinology, Department of Internal Medicine, Kanazawa Medical University
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MORIMOTO SHINPEI
Division of Endocrinology, Department of Internal Medicine, Kanazawa Medical University
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HOSOJIMA HIROYUKI
Division of Endocrinology, Department of Internal Medicine, Kanazawa Medical University
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KAKITA TERUO
Division of Endocrinology, Department of Internal Medicine, Kanazawa Medical University
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AZUKIZAWA SADAHIDE
Division of Endocrinology, Department of Internal Medicine, Kanazawa Medical University
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