Na-K-dependent ATPase in red cells and thyroid status.

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概要

• 論文の詳細を見る

• The Relationship between ouabain-sensitive ATPase (Na-K ATPase) activity in erythrocytes and the thyroid status was studied in 36 patients with Graves' disease and 58 patients receiving L-thyroxine (T4) replacement therapy. Forty normal children served as control. Total ATPase activity in 4 untreated hypothyroid patients was significantly reluced (11.0±4.6 vs 17.3±4.1μg-P/h/mg-protein, P<0.01), and Na-K ATPase was undetectable, both of which were normalized after 4 weeks of L-T4 therapy. Na-K ATPase in hyperthyroid patients was also decreased (0.9±0.8 vs 4.0±2.7, P<0.01), but was gralually normalized after 3 months of euthyroil state.<BR>Clinically euthyroid children treated with L-T4 were divided into 2 groups with regard to Na-K ATPase activity, normal and low. Analysis of the possible factors prolucing this difference revealel that, in primary hypothyroidism, the factor appeared to be the endogenous T4 level, while in patients with dwarfism, the secretory capacity of TSH or TSH-releasing hormone (TRH) was contributory. Thus Na-K ATPase activity in red cells remains within the normal range after L-T4 replacement in the presence of a severe degree of primary hypothyroidism or in association with secondary or tertiary hypothyroidism. Other factors such as the L-T4 dose, duration of the therapy, serum T4 and T3 concentrations, were not significantly different in the two groups. These results indicate that (1) Na-K ATPase in red cells is decreased in hyper-or hypothyroid state, (2) restoration of normal activity requires 1-3 months of euthyroid period, and (3) it is a sensitive index of peripheral thyroid status over the preceding few months.

• 社団法人 日本内分泌学会の論文

著者

• Miyamori Chiaki

  Department Of Pediatrics Kanazawa Red Cross Hospital

• Kato Taizo

  Department Of Dermatology Tohoku University School Of Medicine

• SATO TAMOTU

  Department of Pediatrics, School of Medicine, Kanazawa University

• KAJIWARA SOHEI

  Department of Pediatrics, School of Medicine, Kanazawa University

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