On the Failure of Prostaglandin Synthetase Inhibitor Indometacin to Affect the Osmoregulation of Plasma Arginine Vasopressin in Rats

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概要

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• The role of central endogenous prostaglandin (PG) in the regulation of osmotically mediated vasopressin secretion under normal physiological conditions in rats was studied employing a prostaglandin synthetase inhibitor, indomethacin, and sensitive and specific radioimmunoassay for plasma arginine vasopressin.<BR>A single dosage and doses for two and five days by s. c. injection of 5.0mg/kg BW of indomethacin, which can produce significant depletion of endogenous PG in the hypothalamus, resulted in a high correlation (r>0.9) between plasma arginine vasopressin (pAVP) and plasma osmolality (pOSM). This relation could be fitted to straight lines of the form pAVP=2.1 (pOSM-296)(N=10), pAVP=3.2 (pOSM-298)(N=13) and pAVP=0.9 (pOSM-295.6)(N=10), after i. p.injection with hypertonic saline, for the three dosages, respectively. The control regression lines could be described by relations of the form pAVP=2.9 (pOSM-298)(N=11), pAVP=3.1 (pOSM-299)(N=8) and pAVP=1.1 (pOSM-296.9)(N=13), respectively. The slope and intercepts (on the osmolality axis) were thus comparable with those of the control group, which had not been influenced by plasma urea nitrogen, glucose or blood volume.<BR>These results suggest that the administration of indomethacin did not influence the osmoregulation of AVP directly.<BR>From this evidence, we conclude that central endogenous PG has no primary role in the control of the osmoregulation of arginine vasopressin secretion under normal physiological conditions.

• 社団法人 日本内分泌学会の論文

著者

• Kamoi Kyuzi

  Department Of Internal Medicine Division Of Endocrine And Metabolism Nagaoka Red Cross Hospital

• CUNNINGHAM MICHAEL

  Department of Medicine, Indiana University

• ROBERTSON GARY

  Department of Medicine, Indiana University

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