A case of pituitary gigantism who had two episodes of diabetic ketoacidosis followed by complete recovery of diabetes.
スポンサーリンク
概要
- 論文の詳細を見る
A 17-year-old boy with pituitary gigantism who had two episodes of diabetic ketoacidosis is reported. Glucose tolerance and insulin secretion were evaluated before, during and after each episode of ketoacidosis. The patient was 201 cm tall and weighed 137 kg. Before surgery, his plasma growth hormone level was 3, 000 ng/ml, glucose tolerance was almost normal and insulin response to glucose load was enhanced. He fell into diabetic ketoacidosis twice; 3 weeks after hypophysectomy and one year later after getting the "flu". On each occasion, insulin treatment was needed only temporarily. After the ketoacidosis improved, glucose tolerance and C-peptide responses became nearly normal. Urine C-peptide was low during and immediately after the second episode, but increased to normal following recovery. It is presumed that a pre-operative compensation for the diabetogenic action of excess growth hormone by hyper-secretion of insulin was broken when superimposed stress was added. This is an example in which subnormal insulin response may not be a prerequisite for the occurrence of a severe diabetic state, and decompensated insulin secretion leading to ketoacidosis may not imply permanent damage to the beta cells.
- 社団法人 日本内分泌学会の論文
著者
-
Saito Toshikazu
Division Of Endocrinology And Metabolism Jichi Medical School
-
YOSHIDA SHO
Division of Endocrinology and Metabolism, Department of Medicine, Jichi Medical School
-
SAKAMOTO YOSHIKAZU
Division of Endocrinology and Metabolism, Department of Medicine, Jichi Medical School
-
KUZUYA TAKESHI
Division of Endocrinology and Metabolism, Department of Medicine, Jichi Medical School
-
Saito Toshikazu
Division Of Endocrinology And Metabolism Department Of Medicine Jichi Medical School
-
MATSUDA AYAKO
Division of Endocrinology and Metabolism Jichi Medical School
-
YAMAMOTO KUNIHIRO
Division of Endocrinology and Metabolism Jichi Medical School
-
SAKAMOTO YOSHIKAZU
Division of Endocrinology and Metabolism Jichi Medical School
-
KUZUYA TAKESHI
Division of Endocrinology and Metabolism Jichi Medical School
関連論文
- EFFECTS OF DIETARY SODIUM ON BRAIN ANGIOTENSIN II RECEPTORS IN SPONTANEOUSLY HYPERTENSIVE RATS
- The Importance of Vasopressin in the Mechanism Maintaining Hypertension in the Rat : THE 10th CONFERENCE ON THE PATHOGENESIS OF HYPERTENSION
- Involvement of Arginine Vasopressin and Renal Sodium Handling in Pathogenesis of Hyponatremia in Elderly Patients
- Possible Pre-Cushing's Syndrome Due to an Adrenal Adenoma Incidentally Discovered
- lmmunologically-Related or lncidental Coexistence of Dia-betes Mellitus and Graves' Disease; Discrimination by Anti-GAD Antibody Measurement
- Inhibition by Transforming Growth Factor-β1 of the Cellular Action of Arginine Vasopressin in Cultured Rat Glomerular Mesangial Cells
- Plasma Adrenomedullin Levels in Patients with Non-Insulin Dependent Diabetes Mellitus: Close Relationships with Diabetic Complications
- Inhibition by Adrenomedullin of Arginine Vasopressin-Activated Mitogen-Activated Protein Kinase in Rat Glomerular Mesangial Cells via cAMP Production
- Chronic Hypernatremia Derived from Hypothalamic Dysfunction: Impaired Secretion of Arginine Vasopressin and Enhanced Renal Water Handling
- Clinical Implication of Serial Leptin Measurement in Subjects with Type 2 Diabetes Mellitus
- Crucial Role of Insulin in Leptin Maintenance: Profound Decrease in Serum Leptin by Octreotide Acetate in Insulinoma Subjects
- Inverse Distribution of Serum Sodium and Potassium in Uncontrolled Inpatients with Diabetes Mellitus
- Contribution of a Missense Mutation (Trp64Arg) in β3-Adrenergic Receptor Gene to Multiple Risk Factors in Japanese Men with Hyperuricemia
- Effect of Glycemic Control on Calcium and Phosphorus Handling and Parathyroid Hormone Level in Patients with Non-Insulin-Dependent Diabetes Mellitus
- Direct evidence of altered bone metabolixm caused by all-trans retinoic acid
- VIP Induces the Translocation and Degradation of the α Subunit of G_s Protein in Rat Pituitary GH_4C_1 Cells
- A Quantitative Analysis of Orbital Soft Tissue in Graves Disease Based on B-mode Ultrasonography
- Vasopressin Receptor Antagonists 1) Therapeutic Efficacy of Vasopressin Receptor Antagonists
- SIADH and other hyponatremic disorders:diagnosis and therapeutic problems
- Insulin Secretory Responses in Patients with Glucose Intolerance due to Extra-Pancreatic Causes. Comparison with Idiopathic Diabetes Mellitus
- A case of pituitary gigantism who had two episodes of diabetic ketoacidosis followed by complete recovery of diabetes.
- A Case of Insulin-Resistant Diabetes Mellitus Successfully Treated with Plasmapheresis in a Chronic Hemodialyzed Patient(Diabetes Mellitus,General Presentation)