Hypokalemia and Sodium Retention in Patients with Diabetes and Chronic Hepatitis Receiving Insulin and Glycyrrhizin
スポンサーリンク
概要
- 論文の詳細を見る
Of 9 patients with chronic hepatitis treated with intravenous administration of 40 to 200mg/day of glycyrrhizin, 3 diabetic patients receiving concomitant insulin developed hypokalemia, sodium retention and suppression of both plasma aldosterone concentration and plasma renin activity after the administration for 3 to 6days. In the remanining 6 patients (5 nondiabetic and 1 diabetic) receiving no insulin, the administration over the long term (18 to 266days) never caused these abnormalites.<BR>The development of hypokalemia and sodium retention in the patients was not associated with increased urinary excretion of potassium, indicating a different condition from pseudoaldosteronism caused by the desoxycorticosterone-like action of glycyrrhizin. These findings suggest that insulin which is known to have hypok alemic, antinatriuretic and antikaliuretic activity, as well as glycyrrhizin plays an important pathogenetic role in the observed electrolyte disturbance, and suppression of both renin and aldosterone.
- 社団法人 日本内分泌学会の論文
著者
-
Kikkawa Ryuichi
Third Department Of Medicine Shiga University Of Medical Science
-
Shigeta Yukio
Third Department Of Medicine Shiga University Of Medical Science
-
FUJIWARA YOSHIHIRO
Third Department of Medicine, Shiga University of Medical Science
-
NAKATA KAZUHIRO
Third Department of Medicine, Shiga University of Medical Science
-
KITAMURA EISAKU
Third Department of Medicine, Shiga University of Medical Science
-
TAKAMA TOSHIRO
Third Department of Medicine, Shiga University of Medical Science
関連論文
- Blood Pressure Control in Japanese Hypertensives with or without Type 2 Diabetes Mellitus
- The Sera from GM1 Ganglioside Antibody Positive Patients with Guillain-Barre Syndrome or Chronic Inflammatory Demyelinating Polyneuropathy Blocks Na^+ Currents in Rat Single Myelinated Nerve Fibers
- High Glucose-Induced Abnormal Epidermal Growth Factor Signaling^1
- β-Sitosterolemia with Generalized Eruptive Xanthomatosis
- Effects of an HMG-CoA Reductase Inhibitor, Pravastatin, and Bile Sequestering Resin, Cholestyramine, on Plasma Plant Sterol Levels in Hypercholesterolemic Subjects
- Insulin-like growth factor I stimulates glucose uptake and expression of glucose transporter 1 in cultured mesangial cells
- Pathogenesis of Diabetic Nephropathy
- Hypokalemia and Sodium Retention in Patients with Diabetes and Chronic Hepatitis Receiving Insulin and Glycyrrhizin