HORMONAL REGULATION OF PARAFOLLICULAR CELL IN THYROID GLAND
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概要
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Hormonal regulation of parafollicular cells (p-cells) was investigated cytologically in 60-days-old male rats of Wistar strain. In the normal control rats, p-cells were divided into 4 types by their cytological features, representing resting, two intermediate and secretory phase. The possible transformation between the pcells and the common follicular cells (c-cells) was suggested in the cytological observation on normal rats.Factors affecting the proliferation of p-cells were thyroxine, hypophysectomy, sialoadenectomy, adrenalectomy and posterior lobe hormone in descending sequence. The neoformation of follicles subsequent to the proliferation of p-cells appeared to be the compensatory response to the atrophy of common follicles. The hyperplasia of p-cells was in equilibrium with the synchronized atrophy of common follicles.Factors affecting the neoformation of follicles due to the hyperplasia of c-cells were TSH, goitrogen and TRF (thyrotrophin releasing factor of Shibusawa); in particular, the action of TRF is most prominent in proliferating potency. On the contrary, the p-cells were diminished in number or disappeared by the administration of the compounds. The neoformation of follicles in thyroid gland, therefore, inhered in two formulae, conditioned respectively on p-cells and c-cells. Electron microscopy was made on the proliferated p-cells in the hypophysectomized rats. The ultrastructure of p-cells may account for the possible secretory activity. An assumption was drawn in present investigation that the reversible transformation between p-cells and c-cells is controlled by TSH.
- 一般社団法人 日本内分泌学会の論文