EFFECT OF DIETARY CHOLESTEROL ON ITS BIOSYNTHESIS IN PARABIOTIC RATS
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概要
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The experiments on parabiotic rats, as here reported, confirm observations of other workers that dietry cholesterol is absorbed and deposited in the tissues of rats.They show moreover that in parabiotic pairs of animals cholesterol which is fed to one of the partners is carried evidently by the blood stream to the companion. This work supports the suggestion of Borgstroem <I>et al</I>.that dietary cholesterol is retained for a time and to a certain degree in the intestinal wall and subsequently in the liver before it is released into the circulation to be carried to other tissues in the body. When both partners are fed cholesterol an even distribution of this substance is found and both fed animals of a pair show the known effect of cholesterol feeding on the incorporation of radioactivity from injected acetate-1-C<SUP>14</SUP>, in a considerably decreased incorporation of C<SUP>14</SUP> into the newly synthesized cholesterol of the liver. In other tissues there is however much less decrease of the incorporation into this substance. The experiments suggest that if there is any extrahepatic biosynthesis of cholesterol in the intact animal, it may be only of quite minor importance in the total picture. When only one of the partners of a pair is fed cholesterol, the synthesis-depressing effect is observed only in the partner which received the feeding while the companion shows a normal incorporation of the radioactive label. Even an amount of cholesterol which does not visibly increase the deposition of this material in the liver has a very definite depressing influence on the incorporation of C<SUP>14</SUP> from acetate-1-C<SUP>14</SUP> into liver cholesterol.
- 一般社団法人 日本内分泌学会の論文
著者
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SCHWENK ERWIN
Department of Pharmacology, University of Puerto Rico and Worcester Foundation for Experimental Biology
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OMORI YOSHIHITO
Department of Pharmacology, University of Puerto Rico and Worcester Foundation for Experimental Biology