BIOCHEMICAL STUDIES ON THE DRUG METABOLISM II. THE EFFECTS OF SOME STEROIDS ON THE METABOLISM OF CYCLOBARBITAL

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No effect on cyclobarbital (EHB) metabolism by rat liver slices was shown by the addition of testosterone or estradiol <I>in vitro</I>.No difference was found in TPNH oxidase activities of intact male or female and castrated male rat liver.The administration of ethionine to rats prolonged the duration of EHB hypnosis.<BR>19-Nortestosterone derivatives shortened the duration of EHB hypnosis in castrated male or intact female rats.The stimulatory effects of steroids on the EHB metabolizing activity of rat liver seemed to be related with anabolic activity rather than with androgenic activity.Piperidino-, pyrrolidino-, and morpholino-ethyl ethers of estrone or estradiol were prepared and their biological effects were examined.They inhibited the uterine growth induced by estrone but had some estrogenic activities.In the rats pretreated with morpholinoethylether of estradiol, testis or seminal vesicle and prostate atrophied and EHB metabolizing activity of liver homogenate was remarkably diminished.
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