A NEW SCREENING METHOD FOR ANTIDIABETICS BASED ON THE INTRAVENOUS GLUCOSE TOLERANCE TEST IN RABBITS

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概要

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• Effect of some antidiabetics on the blood sugar curve after intravenous injection of glucose was investigated with the rabbits pre-treated with priscoline. Since an action of priscoline was found to make the curve type exponential, configuration of glucose tolerance curve could be determined by two constants, <I>e<SUP>-k</SUP></I> and <I>C</I> in a formula <I>y<SUB>t</SUB></I>=<I>ae<SUP>-kt</SUP></I>+<I>C</I> (<I>y</I>, blood sugar level; <I>t</I>, time; <I>a</I>, initial blood sugar).<BR>Influences of antidiabetics, insulin, tolbutamide (N-toluyl-sulfonyl-N'-butylurea), metformin (Dimethylbiguanide) and sodium mesoxalate injected intravenously, were as follows:<BR>(1)<I>Examinations after single administration</I>a) After administration of 0.05u./kg of regular insulin, <I>e<SUP>-k</SUP></I> and <I>C </I>became both smaller than those for control. They were influenced in the similar way by subcutaneous injection of 0.1u./kg. b) After injection of 100mg/kg of tolbutamide, <I>C</I> value decreased significantly without change in e-k value. c) 50mg/kg of metformin gave an increasing effect on both of the two constants.<BR>(2) <I>Examinations after repeated administrations</I>After the administrations of 100mg/kg of sodium mesoxalate during 5 or 10 days, <I>e<SUP>-k</SUP> </I>became smaller but Clarger.<BR>(3) There were not any changes in <I>e<SUP>-k</SUP></I> and I values at ter single administration of 100mg/kg of the mesoxalate, or after the repeated administrations of 0.05u./kg of insulin, 100mg/kg of tolbutamide or 31mg/kg of the mesoxalate.<BR>Mechanism of these actions was briefly referred to, and a possibility was discussed to apply this glucose tolerance test to the pharmacological screening method for antidiabetics.

• 社団法人 日本内分泌学会の論文

著者

• TAKEUCHI S.

  Department of Anatomy, Shimane Medical University

• TOBE MASUO

  Department of Pharmacology, Nippon Medical School

• SASAKI TOSHIKO

  Department of Pharmacology, Nippon Medical School

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