EFFECT OF GOLDTHIOGLUCOSE UPON NEUROSECRETORY CELLS IN THE HYPOTHALAMUS OF AMPHIBIA
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概要
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Goldthioglucose was intraperitoneally injected into Bufo vulgaris japonicus which was collected in July, August and November.<BR>The evidences obtained from this experiment were as follows:<BR>1) After the injection of goldthioglucose, a large amount of CH-positive substance appeared in the neurosecretory cells, axones and interstitial tissues in the preoptic area. In axones, so-called "perlschnurartige Anordnung" was exhibited.<BR>a) The quantitative change of neurosecretory substance in the preoptic area was diphasic or more.<BR>b) The susceptibility of the preoptic nucleus to goldthioglucose varied with sex of animal and the season in which the experiment was performed.<BR>2) The action of goldthioglucose can be considered to be due to its gold molecule.<BR>a) The injection of gold chloride increased. CH-positive substance in the axones.<BR>b) The injection of sodium thioglycollate did not elicit any remarkable change in the preoptic area.<BR>3) Two kinds of neurosecretory substance which were distinguishable with azan staining were in both positive to PAS reaction even after digestion with saliva.
- 一般社団法人 日本内分泌学会の論文