COINCIDENTAL REBOUND PHENOMENA OF THYROID FUNCTION AND NEUROSECRETORY SUBSTANCE IN THE NEUROHYPOPHYSIS FOLLOWING METHYLTHIOURACIL OR THYROXINE WITHDRAWAL IN THE RATS

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概要

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• Comparison of the effects of MTU and T<SUB>4</SUB> withdrawal on different thyroid parameters has been made in the rat. After the withdrawal of chronic MTU treatment, marked rebound in thyroidal <SUP>131</SUP>I uptake and conversion ratio was produced but not in thyroid weight, while no rebound was produced in any of thyroid parameters after a single injection of MTU. After a single injection of T<SUB>4</SUB>, however, pronounced rebound was produced in thyroidal <SUP>131</SUP>I uptake, conversion ratio and thyroid weight.<BR>A similar type of rebound of neurosecretory substance was also produced after the withdrawal of chronic MTU treatment.<BR>It is postulated that the difference in the response of thyroid weight might be related to different pattern of circulating TSH. Possible participation of hypothalamic neurosecretory system for the production of rebound phenomena is discussed.

• 社団法人 日本内分泌学会の論文

著者

• SHIMODA SHIN-ICHI

  First Department of Internal Medicine, School of Medicine, Gunma University

関連論文

• COINCIDENTAL REBOUND PHENOMENA OF THYROID FUNCTION AND NEUROSECRETORY SUBSTANCE IN THE NEUROHYPOPHYSIS FOLLOWING METHYLTHIOURACIL OR THYROXINE WITHDRAWAL IN THE RATS
• Recovery of Thyroid Hormone Biosynthesis after a Single Injection of Methylthiouracil as Judged by Thyroidal Radioiodine Uptake, Thyroidal Protein-Bound Iodine, Thyroidal Radioiodinated Amino Acids and Thyroglobulin in the Rat

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