メカニカルアンフォールディング研究の最前線―タンパク質を引っ張ってみてわかること―

概要

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Using atomic force microscopy technique, it is capable of picking up a single protein molecule to apply a mechanical force. This technique, called “force spectroscopy”, provides unique information about the intermediates and the free energy landscape of the mechanical unfolding of proteins. In this review we introduce recent studies that answer some fundamental questions: “Is the mechanical resistance of protein isotropic?”, “What is the structure of the transition state in the mechanical unfolding like?” and “Is the mechanical unfolding related to biological functions?”.