白金ブルー錯体の合成とその性質

概要

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Since the first report in 1908, a class of platinum compounds called “platinum blues” have attracted interests of chemists because of their unusual dark blue color. However, because of the difficulty in isolating and crystallizing the complexes, their formulas and structures have been left unclarified till a decade ago. About ten years ago when it turned out that the famous anti-tumor complex cis-Pt (NH3) 2CL2 effects its activity by binding to DNA and obstructing the DNA duplication, a study regarding the coordination reaction of cis-Pt (NH3) 2Cl2 with pyrimidine bases started and the platinum pyrimidine blues found in the study again aroused interest of chemists. In the course of intensive studies, the first crystal structure determination of platinum blue was carried out for a compound with α-pyridone as a pyrimidine model and the tetranuclear 5+ mixed-valent chain structure of [Pt4 (NH3) 8 (C5H4NO) 4] was revealed. In the present article, syntheses, structures and chemical properties of platinum blues and several other related multinuclear platinum complexes containing hetero metal atoms are surveyed with an emphasis on the specific nature of amidate ligands that stabilize unusually high oxidation state of metals.
社団法人有機合成化学協会の論文