生体系におけるホストーゲストケミストリー : DNAの分子認識

概要

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Interactions between DNA and DNA binding proteins, and between DNA and small biologically active molecules are central to many of the vital processes in biological systems. Two types of mode of DNA-ligand interactions, i.e., intercalation between the base pairs of DNA, and binding in the grooves of DNA, are reviewd, focusing on the structural aspects. DNA binding proteins include sequence non-specific gene 5 protein from bacteriophage fd and DNase I, as well as highly sequence specific restriction enzyme Eco RI. Effects of methylation on the recognition sequence will be discussed. Detailed interactions observed between the groove binding antibiotic netropsin and d (CGCGAATTCGCG) <SUB>2</SUB> or d (CGCGATATCGCG) <SUB>2</SUB> will be compared. Finally, our recent work on new DNA cleaving agents with groove preference is briefly mentioned.
社団法人有機合成化学協会の論文