芳香族フッ素化合物の合成 : ハロゲン交換フッ素化法において, フッ化カリウムの反応性を高める手段

概要

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The title reactions have been widely utilized in a laboratory and an industrial use for the preparation of aromatic fluoride derivatives. The advantage is a simple and convenient procedure which is avoidable the use of dangerous hydrogen fluoride. However, owing to poor solubilities of metal fluorides (mainly potassium fluoride) in organic solvents, the halogen-exchange fluorination with these reagents often requires elevated temperatures in polar solvents, which are accompanied by the decomposition of the starting substrates and/or products. In this article, numerous devotions will be reviewed to enhance the activity of potassium fluoride from the literature published since 198O.
社団法人有機合成化学協会の論文