エナンチオ選択的およびジアステレオ選択的オレフィン水素化の進歩
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概要
- 論文の詳細を見る
Asymmetric homogeneous hydrogenation of a-acylaminoacrylic acids and analogs, catalyzed by rhodium (I) complexes containing a variety of optically active diphosphines which render the chiral information through the metal center to the substrate, became one of the most successful and well-understood catalytic reactions during these two decades.<BR>A case study of the improvement of enantioselectivity in the rhodium (I) -catalyzed hydrogenation of 3-phenyl-3-butenoic acid, a substrate with rather weakly coordinating ability, is discussed.<BR>Highly versatile asymmetric catalytic hyderogenation of prochiral acrylic acids with use of new Ru (II) -BI-NAP complexes as catalyst precursors is briefly described.<BR>In order to achieve the high level of enantioselective hydrogenation and diastereoselective one as well, a necessary assistance of the proximate functional groups in either prochiral or chiral olefin substrates for making a chelate coordination to the catalyst is exemplified, typically in the hydroxy or carbamoyl group-directed hydrogenation of allylic alcohols and allylic carbamates, respectively.
- 社団法人 有機合成化学協会の論文