甲殻類の脱皮に関与するホルモン
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概要
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The presence of a molt-inhibiting hormone (MIH) in crustaceans versus the molting hormone (ecdysteroids) has been biologically demonstrated, however, only a little of the chemical nature of MIH is known so far Our attempt to isolate MIH produced in the X-organ of the eyestalks (ES) resulted in the characterization of xanthurenic acid as an ecdysone biosynthesis inhibitor (EBI) In addition, it was found that 3-hydroxy-L-kynurenine (3-OH-K) present in the X-organ of ES was also biotransformed into xanthurenic acid. The inhibitory action was shown in the cultured Y-organ-complex homogenate as well as in the crayfish by injection of 3-OH-K that revealed the delay of ecdysis. The preliminary study of ED<SUB>50</SUB> of the active compounds appeared to account for most of but not the full potency of ES extract. Therefore, a molt-inhibiting phenomena is probably the result of the action by the multiple factors including EBI. After the mode of inhibitory action of the recently isolated sinusgland neuropeptide is shown, the involvement of a hormone in the negative control of molting will be clarified.
- 社団法人 有機合成化学協会の論文