光学活性スルホキシドを不斉源とする天然有機化合物の合成

概要

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Three types of asymmetric reactions induced by chiral sulfoxides are described as follows : (1) 1, 3-Asymmetric induction in the addition of organoaluminum reagents to chiral β-ketosulfoxides. (2) New synthetic method for optically pure α, β-unsaturated sulfoxides, and additive Pummerer reaction of 1-alkenyl sulfoxides with dichloroketene. (3) 1, 4-Asymmetric induction in the rearrangement of α-p-tolylsulfinyl-α, β-enoates. Utility of the present methodologies is illustrated by the asymmetric syntheses of marine prostanoids and bibenzyl lignan lactones.
社団法人有機合成化学協会の論文