高効率ペプチド合成 : 多種品目同時自動合成とペプチドライブラリー

概要

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The need for high-quality synthetic peptides has been greatly increased due to the expansion of life-science research. Production of polypeptides by genetic engineering has been more and more popular. However, chemical synthesis is still indispensable for production of peptides containing unusual amino acids or peptides with a C-terminal amide. At the present time chemical synthesis is definitely preferable for the preparation of peptides with up to 30 amino acid residues. This article will focus on highly efficient synthesis, which involves rapid synthesis using automated simultaneous multiple solid-phase synthesis with high yield and high homogeneity of synthetic products, safe operation with a small amount of waste, low cost hardware and low running cost. Reagents, solid-supports, a novel synthesizer without cross-contamination, simultaneous cleavage for highly efficient synthesis and characterization of synthetic peptides, and additionally the construction of peptide library are reviewed.
社団法人有機合成化学協会の論文