有機溶媒中における活性メチレン化合物の反応

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概要

• 論文の詳細を見る

• The malonic acid synthesis is usually performed in the presence of strong bases.In the present study, however, it was found that the reaction readily took placewhen aweak base such as sodium bicarbonate was used in polar organic solvents, such as dimethyl formamide and dimethyl sulfoxide. Ethyl malonate was thus treated with benzyl chloride in dimethyl formamide in the presence of sodium bicarbonate at125.. for 1 hr to obtain the mono-and di-benzylmalonates. Similar reactions also occured in dimethyl sulfoxide, but not in cyclohexanone, cyclohexanol, and n-butanol.Other active methylene compounds such as methyl acetoacetate and other chlorides such as ethyl monochloroacetate were slso used too establish the versatility of the reaction. The effects of the water added to the solvent were also investigated.

• 社団法人 有機合成化学協会の論文

著者

• 佐藤 成美

  名古屋工業大学工業教員養成所

• 佐々木 宏

  名古屋工業大学工業教員養成所

• 中村 正夫

  名古屋工業大学工業教員養成所

関連論文

• 有機溶媒中における活性メチレン化合物の反応

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