7-置換フラボン類の合成

概要

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For the purpose of preparing 7-flavonylmethyl carbamate derivatives, syntheses of a series of 7-substituted flavones were attempted by use of 7-hydroxyflavone as a starting material.<BR>The following 7-substituted flavones have been prepared, namely, 7-haloflavones, 7-cyanoflavone, flavone-7-carboxylic acid and related derivatives, 7-hydroxymethyl-flavone, and 7-flavonylmethyl carbamate derivatives.<BR>In the case of the synthesis of 7-hydroxymethylflavone, the reduction of the ester group in flavone derivatives was studied and it was found that ethyl-7-flavonoxyacetate was converted into 7- (hydroxyethoxy) -flavone in good yield at low temperature with lithiumaluminum hydride.<BR>Some β (7-flavonoxy) ethyl carbamate derivatives have also been prepared.
社団法人有機合成化学協会の論文