プロテアーゼ阻害剤を目的とした (<I>E</I>) -アルケン・ジペプチド・イソスターの高選択的合成

概要

論文の詳細を見る
Syntheses of protected dipeptide isosteres bearing a trans carbon-carbon double bond in place of the amide linkage are described. Complete stereochemical control is employed in the synthesis of some biologically important isosteres with an alkyl group at the α-position of the δ-aminated β, γ-unsaturated esters. The synthesized isosteres have been incorporated into natural peptide analogues. The biological activites of some of alkene isosteres and peptide analogues are also presented.
社団法人有機合成化学協会の論文