合成アプローチからの生理活性物質の探索 : 含硫黄複素環化合物の合成を中心に

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Recently, a variety of S, N-heterocycles has been developed to the useful and practical drugs in agrochemicals and medicines. Under this circumstance, we paid our attention to these heterocycles as screening target compounds, to create new bioactive heterocycles. As a methodology to search for the new lead compounds, we focussed on the synthetic development of S, N-heterocycles. In result, this synthetic approach led to the generation of heterocycles with either the insecticidal or the anti-PAF activity. On the basis of their structureactivity relationships, these heterocycles were extended to the optimized compounds leading to novel bioactive heterocycles, triazolobenzothiazoles and thiazolidin-4-ones. In this article, the synthetic approach to S, N-heterocycles with biological activities is described.