オキシゲナ-ゼのモデル (有機合成における金属含有酵素<特集>)
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概要
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It is of particular importance to understand the reaction of oxygenases not only in view of the biological significance but also in the synthetic chemical point of view. Many oxygenases contain metal ions, which participate in the reaction center to play an important rôle for activation process of the reactions. The molecular mechanisms for the reactions of oxygenases are still remained obscure, although an "oxenoid mechanism" is now generally believed for the reactions of monooxygenases. In spite of many attempts to illucidate the enzyme reactions through various metal complex-catalyzed oxygenation of organic molecules as models for the monooxygenases, nearly nothing has been made clear even on the mechanisms of the model systems, particularly for the aromatic hydroxylation. It is suggested that FeO is a possible reactive species in common with the model aromatic hydroxylation systems.<BR>In some models for the reactions of dioxygenases quite high selectivity has been recognized and peroxy complex intermediates are considered for these models, and some such a model peroxy interme-diates are isolated. Some characteristics, chemical properties of model intermediates, and plausible mechanisms for these reactions are discussed.
- 社団法人 有機合成化学協会の論文