免疫抑制剤 (-) -FK-506の全合成と生物学
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概要
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The unique chemical structure of the FK-506 has attracted many synthetic organic chemists for its total synthesis. This review describes our completion of the total synthesis of (-) -FK-506. The biochemical and molecular events associated with lymphocyte activation are currently among the most well-studied in biology. These highly complex cells are of interest not only because they serve as a model system for elucidating events involved in transmitting signals between cell surface receptors and the nucleus, but also because of the important role that lymphocytes play in a variety of clinically relevant diseases. The observation that the major receptor for FK-506, FKBP, forms a complex with calcineurin, a calcium-calmodulin dependent phosphatase, opens new possibilities for our understanding of signal transduction and for the design of novel immunosuppressants.
- 社団法人 有機合成化学協会の論文