酵素を用いるオリゴ糖の合成
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概要
- 論文の詳細を見る
Development of cloning techniques have made several glycosyltransferases available for organic chemists. Enzymatic synthesis of oligosaccharides using glycosyltransferases show, high regio- and stereospecific glycosidic bond formations without protecting groups of hydroxyl groups. In this review, we describe recent developments in oligosaccharide synthesis employing sialyl-, galactosyl- and fucosyltransferase, which are necessary for the synthesis of sialyl Lewis X tetrasaccharide. Application of in situ cofactor regeneration systems avoids the tedious separate preparation of sugar nucleotide, and inhibition caused by the released nucleoside mono- or diphosphates.
- 社団法人 有機合成化学協会の論文