含硫植物毒 : Malforminとアスパラガス酸 (Asparagusic Acid) について
スポンサーリンク
概要
- 論文の詳細を見る
Malformins are cyclic pentapeptides which were isolated from the culture filtrate of the fungi of Aspergillus niger group as compounds causing curvatures on corn roots and malformations on the stems and petioles of bean plants. Malformin A (A<SUB>1</SUB>>A<SUB>2</SUB>), B (B<SUB>1</SUB>+B<SUB>2</SUB>), and C are known. Malformin A is cyclo-D-cysteinyl-D-cysteinyl-L-valyl-D-leucyl-L-isoleucyl. Malformin has a variety of biological activities : it inhibits adventitious root formation, stimulates abscission, inhibits ethylene- and phytochrome-mediated responses, potentiates and inhibits the effects of 2-chloroethylphosphonic acid, and also stimulates the stem elongation of bean seedlings or cuttings. A palindrome peptide, <I>enantio</I>- [5-valine] malformin, which was synthesized chemically, has one-tenth of activities of the natural malformin. Desthiomalformin has no activity showing the importance of the disulfide group of malformin.<BR>Asparagusic acids, 1, 2-dithiolane-4-carboxylic acid and its derivatives, were isolated from <I>Asparagus</I> as compounds inhibiting lettuce seed germination and lettuce root and hypocotyl elongation. Asparagusic acid interacts with benzyladenine in radish cotyledon growth and lettuce seed germination and inhibits the activities of gibberellic acid and indoleacetic acid. Moreover asparagusic acid, which is structurally similar to lipoic acid, accelerates the biochemical oxidation of α-keto acids which is catalyzed by lipoic acid <I>in vivo</I>. The disulfide group and carboxylic acid are important in the activities of asparagusic acid.
- 社団法人 有機合成化学協会の論文