リン錯体を触媒とする不斉合成--新しい不斉Pyrrolidinephosphine錯体
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概要
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Syntheses of new chiral pyrrolidinephosphine ligands (BPPM, BZPPM, PPPM, etc) from L-hydroxyproline and their application to the syntheses of optically active compounds were described. Thus, α-amino acids (8391% optical yields), salsolidine (45%), α-hydroxy esters (78.5%), R- (-) -pantolactone (80.586.7%), β-amino acids (5355.2%), α-methylsuccinic acid (94.2%) and β-methylaspartic acid (58.2%) were obtained.<BR>Finally, the mechanism of their asymmetric hydrogenation was also discussed.
- 社団法人 有機合成化学協会の論文