1,2位に含窒素5員環が縮合した,1,4-ベンゾジアゼピン類の合成とCNS活性 (「医薬品開発をめぐる生理活性物質の合成」特集号)

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This article reviews the syntheses of 1, 4-benzodiazepines with a nitrogen atom-containing five-membered ring fused to the 1, 2-position of the diazepine ring. Recent work on this class of compounds has yielded new synthetic methodologies and compounds (potentially) useful in medicine. Descriptions are arranged according to types of structures of target tricyclic diazepines and to types of approaches in the synthesis. The activity of the compounds on the central nervous system (CNS) is also mentioned. Contents : 1. Introduction, 2. 4H-pyrrolo [1, 2-a] [1, 4] benzodiazepines, 3. 4H-imidazo [1, 2-a] [1, 4] benzodiazepines, 4. 4H-imidazo [1, 5- a] [1, 4] benzodiazepines, 5. 4H-pyrazolo [1, 5- a] [1, 4] benzodiazepines, 6. 4H-s-triazolo [4, 3- a] [1, 4] benzodiazepines, 7. 4H-s-triazolo [1, 5-a] [1, 4] benzodiazepines, 8. 4H-υ-triazolo [1, 5-a] [1, 4] benzodiazepines, 9. 4 H-tetrazolo [1, 5-a] [1, 4] benzodiazepines, 10. CNS activity, 11. Closing comment.
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