新農薬イソプロチオランの発見と開発

概要

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In the studies on the application of organic sulfur compounds in agricultural fungicides, some derivatives of ketene thioacetals were found to be effective for the control of rice blast. This original, serendipitous discovery prompted an extensive synthetic and screening program, which shed considerable light on the relationship between chemical structure, and biological activity.<BR>As a result, isoprothiolane, diisopropyl 1, 3-dithiolan-2-ylidenemalonate, 5e was selected as being the most potent compound for the control of rice blast. During the research program, this fungicide was found to be able to control the several species of planthoppers in paddy field. Isoprothiolane was developed as a new systemic pesticide for the control of rice blast and planthoppers.<BR>This paper descrives the discovery and development of isoprothiolane.
社団法人有機合成化学協会の論文