2-メチレングルタロニトリルの化学
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概要
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2-Methyleneglutaronitrile (MGN) is a unique trifunctional compound because of the combination of the vinylidene group with the two cyano groups. It is a useful intermediate in organic syntheses for making polymers, pharmaceuticals and other special chemicals.<BR>Since the early 1960s the catalytic dimerization of acrylonitrile (AN) to MGN has been actively investigated using mainly trivalent phosphorus compounds. However, until a few years ago, MGN had not been industrially used, because an economical way for its production on a large scale did not exist. We now produce MGN on a commercial scale by the dimerization of AN with a catalyst consisting of metal halide and tertiary amine.<BR>This paper describes the preparation and chemistry of MGN with the intention of stimulating future applications. The physical and toxicological properties of MGN are also mentioned briefly.
- 社団法人 有機合成化学協会の論文