アミノ糖抗生物質誘導体の工業的製造について
スポンサーリンク
概要
- 論文の詳細を見る
On the basis of the mechanism of aminoglycoside antibiotic resistance, a number of semisynthetic derivatives of aminoglycoside antibiotics have been synthesized by deoxygenation and acylation. Among them, 3', 4'-dideoxykanamycin B (Dibekacin) and 1-<I>N</I>- [(<I>S</I>) -4-amino-2-hydroxybutyryl] kanamycin A (Amikacin) have been commercialized and now widely used clinically. Dibekacin is demonstrated by our improvement on the industrial synthesis and Amikacin is reviewed from the view point of methodology of the selective acylation.
- 社団法人 有機合成化学協会の論文