Glucose Transporter-mediated Dynamic Attachment of Erythrocytes onto a Reducing Glucose-carrying Polystyrene.

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概要

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• Erythrocytes, which carry type-1 glucose transporters (GLUT-1) in their plasma membrane, were found to attach specifically and strongly to dishes which had been coated with a polystyrene derivative (PVG) substituted with reducing glucose moieties. The concave erythrocytes took teardrop shapes, stood on the rim, and swayed with gentle disturbance in the medium. In contrast, erythrocytes attached by nonspecific hydrophobic interaction on uncoated polystyrene dishes assumed fiat morphology and remained unperturbed by movements in the medium. The attachment to PVG substratum was suppressed by (1) GLUT-1 inhibitors such as phloretin, phloridzin, and cytochalasin B, and (2) PVG molecules in solution, and (3) at 4°C, suggesting that the specific recognition of high density of glucose on PVG and the dynamic movement of GLUT-1 are essential for the attachment. This novel combination of glucose transporter-carrying cells and reducing glucose-carrying polymer may lead to biomaterials with a wide range of applications.

• 日本学士院の論文

著者

• Koyama Atsuhiro

  Department Of Mechanical Engineering And Systems Graduate School Of Engineering Osaka University

• Goto Mitsuaki

  Kanagawa Academy Of Science And Technology

• KOBAYASHI Akira

  Kanagawa Academy of Science and Technology

• KOBAYASHI Kazukiyo

  Faculty of Agriculture, Nagoya University

• CHANG Chia-Wun

  Kanagawa Academy of Science and Technology

• TOMITA Kosuke

  Department of Engineering, Kantogakuin University

• AKAIKE Toshihiro

  Kanagawa Academy of Science and Technology

• KOYAMA Atsuhiro

  Department of Engineering, Kantogakuin University

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• Glucose Transporter-mediated Dynamic Attachment of Erythrocytes onto a Reducing Glucose-carrying Polystyrene.

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