Sequence Variation of Human Platelet Membrane Glycoprotein IIIa Associated with the Yuka/Yukb Alloantigen System.

スポンサーリンク

概要

• 論文の詳細を見る

• The human platelet alloantigens play a prominent role in provoking neonatal alloimmune thrombocytopenic purpura. The frequencies of Yuka and Yukb antigens are 1.7% and 99.9% in the Japanese population, respectively. The Yuk alloantigen system is localized on the human platelet membrane glycoprotein (GP)IIIa. To investigate the molecular structure of Yuk alloantigenic determinants, we amplified GP IIIa cDNAs from Yuka/a and Yukb/b homozygous individuals. A single nucleotide substitution was found at base 526 of GP IIIa cDNA by direct DNA sequencing analysis. The Yukb/b homozygous individuals bore G at this position while the Yuka/a had A. This base change results in the substitution of glutamine in Yuka for arginine in Yukb at amino acid residue 143 of glycoprotein IIIa molecule. Slot blotting analysis using sequence-specific oligonucleotide probes demonstrated that this Arg/Gln polymorphism is associated with the Yuk alloantigen system.

• 日本学士院の論文

著者

• Kuwata Shoji

  Blood Transfusion Service The University Of Tokyo

• TOKUNAGA Katsushi

  Blood Transfusion Service, Faculty of Medicine, University of Tokyo

• SHIBATA Yoichi

  Department of Hokuriku Lowland Farming, Hokuriku Research Center, National Agricultural Research Center

• KUWATA Shoji

  Blood Transfusion Service, Faculty of Medicine, University of Tokyo

• WANG Li

  Blood Transfusion Service, Faculty of Medicine, University of Tokyo

• JUJI Takeo

  Blood Transfusion Service, Faculty of Medicine, University of Tokyo

関連論文

• Decreased Synthesis of Matrix Metalloproteinase-7 and Adhesion to the Extracellular Matrix Proteins of Human Colon Cancer Cells Treated with Troglitazone
• Dendritic cell immunotherapy for patients with metastatic renal cell carcinoma : University of Tokyo experience
• Vaccination with autologous endothelium inhibits angiogenesis and metastasis of colon cancer through autoimmunity
• Expression of platelet-derived endothelial cell growth factor in inflammatory bowel disease
• Effects of Recombinant Human Erythropoietin Therapy on Blood Coagulation and Fibrinolysis System
• Perinatal intracranial hemorrhage due to severe neonatal alloimmune thrombocytopenic purpura (NAITP) associated with anti-Yuk^b (HPA-4a) antibodies
• Functional expression of β1 and β2 integrins on tumor infiltrating lymphocytes (TILs) in colorectal cancer
• Study of aspartate at residue 9 of HLA-C molecules in Japanese patients with psoriasis vulgaris
• Yield Monitoring System for a Head-Feeding Combine
• Sequence Variation of Human Platelet Membrane Glycoprotein IIIa Associated with the Yuka/Yukb Alloantigen System.

スポンサーリンク