Temporary expression of A31 mRNA in nascent dendrites of human fetal brain
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概要
- 論文の詳細を見る
A modified differential display method was used to compare patterns of mRNA expression between human fetal and adult brains and we obtained 26 candidates for highly expressed fetal cDNA fragments. A clone, A31, was picked up, which had no significant homology in sequence compared with the DDBJ/EMBL/GenBank databases. A31 mRNA was shown to be expressed only in fetal brain by RT-PCR and Northern blotting. The Northern analysis revealed that the mRNA was about 9kb and highly expressed in middle stage of human brain, and that it was absent in various tissues except brain. Further characterization of this clone was performed by in situ hybridization, which showed that the mRNA was mostly expressed in cell bodies and dendrites of neurons in cortical plates. Our analyses suggest that this mRNA is involved in dendritic development at the middle stage in human fetal brain and that the mRNA is partially transported from cell bodies to dendrites where the protein is synthesized.
- 日本学士院の論文
著者
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TAKASHIMA Sachio
Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, NCNP
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Yasuda Shigeru
Department Of Neurosurgery Iwate Medical University
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YASUKOCHI Yukio
Department of Molecular Genetics, Medical Research Institute, Tokyo Medical and Dental University
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TORU Michio
Department of Neuropsychiatry, School of Medicine, Tokyo Medical and Dental University
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Takashima Sachio
Department Of Mental Retardation And Birth Defect Resarch National Center Of Neurology And Psychiatr
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Toru Michio
Department Of Neuropsychiatry Tokyo Medical And Dental University School Of Medicine
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Takashima Sachio
Department Of Clinical Laboratory National Hospital For Mental Nervous And Muscular Disorders Nation
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Yasukochi Yukio
Department Of Melecular Genetics Medical Research Institute Tokyo Medical And Dental University
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Toru Michio
Department Of Neuropsychiatry School Of Medicine Tokyo Medical & Dental University
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TAKASHIMA Sachio
Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, National Center for Neurology and Psychiatry
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YASUDA Shigeru
Department of Neuropsychiatry, School of Medicine, Tokyo Medical and Dental University
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