The proline rule : A strategy for protein thermal stabilization
スポンサーリンク
概要
- 論文の詳細を見る
The proline rule which was proposed as a general strategy for protein thermal stabilization [Suzuki, Y., Oishi, K., Nakano, H., and Nagayama, T. (1987) Appl. Microbiol. Biotechnol. 26, 546-551] has been examined and refined in the present study. The proline rule in refined form states that thermostability of a globular protein can be additively increased by increasing the frequency of the occurrence of proline residues in the second positions of β-turns (and in the first turns of α-helices or on coils) on the surface of the protein, and that the overall effect on thermostability can be further strengthened by clustering proline residues around flexible regions of the protein.
- 日本学士院の論文
著者
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Suzuki Yuzuru
Department Of Applied Biochemistry Kyoto Prefectural University
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Suzuki Yuzuru
Department Of Agricultural Chemistry Kyoto Prefectural University
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SUZUKI Yuzuru
Department of Applied Biochemistry, Kyoto Prefectural University
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