Direct and systemic effects of endotoxin on renal function.
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The possibility of a direct endotoxin effect on the kidney was studied in dogs. Endotoxin, at a sub-lethal dose (0.05 mg/kg) caused only a slight reduction in systolic blood pressure but a significant reduction in urinary excretion rate of sodium (U<SUB>Na</SUB>·V), effective renal plasma flow (RPF), and glomerular filtration rate (GFR). Neither tubular rejection fraction of sodium (TRF<SUB>Na</SUB>) nor filtration fraction of sodium (F. F.) were changed.The endotoxin effects of a reduction in U<SUB>Na</SUB>·V, RPF, and GFR were blocked by pretreating the animals with phenoxybenzamine (10 mg/dog, intravenously) or propranolol (0.25 mg/kg, intravenously). A direct, left renal arterial infusion of endotoxin (0.02 mg/kg/min) did not alter renal function of either the left or the right kidney. A left renal arterial infusion of phenoxybenzamine or propranolol, did not modify the renal effects of endotoxin, injected into femoral vein in dogs.These findings suggest that a sub-lethal dose of endotoxin may cause stimulation of extra-renal adrenergic receptors of the vasculature which in turn causes reduction in RPF as well as GFR, and ultimately a retention of sodium and other fluids in the body as a defensive mechanism against endotoxic shock.
- 久留米大学医学部 The Kurume Medical Journal 編集部の論文