Effect of a TRH Analog (DN-1417) on Tyrosine Hydroxylase Activity in Discrete Areas of Rat Brain

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概要

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• Tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine biosynthesis was assayed in 12 regions of rat brain following chronic treatment with DN -1417 (γ-butyrolactone-γ-carbonyl-histidyl-prolinamide), a synthetic TRH analog. Chronic DN-1417 treatment (20 mg/kg i. p., 7 daily injections) increased the TH activity in the ventral tegmental area, nucleus arcuatus and nucleus locus coeruleus, and decreased the TH activity in the frontal cortices, olfactory tuberculum and nucleus paraventricularis. No significant change in TH activity was observed in the nucleus accumbens, nucleus caudatus putamen, median eminence and substantia nigra. These results suggest that DN -1417 exerts some of its effects through dopaminergic neurons, as well as noradrenergic neurons; and the mesolimbic and mesocortical dopamine system may be intimately involved in the central actions of DN-1417.

著者

• Hirano Makoto

  Laboratory Of Applied Microbiology Graduate School Of Agriculture Hokkaido University

• Matsumoto Takashi

  Laboratory Of Insect Ecology Graduate School Of Agriculture Kyoto University:(present Address) Labor

• NAKAHARA TATSUO

  Department of Chemistry, Faculty of Science, Kyushu University

• YOKOO HIDEYASU

  Laboratory of Neurochemistry, Hizen National Mental Hospital

• UCHIMURA HIDEYUKI

  Laboratory of Neurochemistry, Hizen National Mental Hospital

• HIRANO MAKOTO

  Laboratory of Neurochemistry, Hizen National Mental Hospital

• MATSUMOTO TAKASHI

  Laboratory of Neurochemistry, Hizen National Mental Hospital

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