Electron microscopic observations of influenzal pneumonitis.

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Influenzal pneumonia was experimentally induced in mice. The respiratory system during the acute phase was investigated by light and electron microscopy. Bronchial desquamation and necrosis were noted from the 2nd day to the 5th day and were most noticeable during the 3rd day. An electron dense degenerative substance was demonstrated in the degenerated epithelial cells on the 2nd and 3rd days. On the 3rd day, flattend basal cells appeared in the large bronchus. The basal cells were covered with one layer of cuboidal or flattened epithelial cells, both ciliated and non-ciliated. The epithelial cells had large nuclei and narrowly restricted cytoplasm. On the 5th day, stratified regenerating epithelial cells lined both the large and small bronchi. In the large bronchus, non-ciliated epithelial cells had cytoplasmic projections. Alveolar epithelial desquamation and necrosis, interstitial pneumonia and collapse of the lung were noted from the 2nd to the 5th day. On the 4th day, the collapse of the lung was most noticeable. No regenerative alveolar epithelium was demon-strated in these experiments.
久留米大学医学部 The Kurume Medical Journal 編集部の論文